Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2010 May 15;20(10):3120-4.

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.

Author information

1
Pfizer Global Research and Development, Chesterfield, MO 63017, United States. michael.tollefson@yahoo.com

Abstract

1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.

PMID:
20443228
DOI:
10.1016/j.bmcl.2010.03.111
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center