Format

Send to

Choose Destination
Histochem Cell Biol. 2010 Jun;133(6):607-26. doi: 10.1007/s00418-010-0701-2. Epub 2010 May 5.

Actin complexes in the cell nucleus: new stones in an old field.

Author information

1
Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.

Abstract

Actin is a well-known protein that has shown a myriad of activities in the cytoplasm. However, recent findings of actin involvement in nuclear processes are overwhelming. Actin complexes in the nucleus range from very dynamic chromatin-remodeling complexes to structural elements of the matrix with single partners known as actin-binding proteins (ABPs). This review summarizes the recent findings of actin-containing complexes in the nucleus. Particular attention is given to key processes like chromatin remodeling, transcription, DNA replication, nucleocytoplasmic transport and to actin roles in nuclear architecture. Understanding the mechanisms involving ABPs will definitely lead us to the principles of the regulation of gene expression performed via concerting nuclear and cytoplasmic processes.

PMID:
20443021
DOI:
10.1007/s00418-010-0701-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center