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Indian J Pharmacol. 2009 Jun;41(3):120-4. doi: 10.4103/0253-7613.55211.

Hepatoprotective and anti-inflammatory activities of Plantago major L.

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1
Departments of Pharmacology and Toxicology, Yüzüncu Yil University, 65300 Van-Turkey.

Abstract

OBJECTIVE:

The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM).

MATERIALS AND METHODS:

Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. HEPATOPROTECTIVE ACTIVITY: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed.

RESULTS:

Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups.

CONCLUSION:

The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities.

KEYWORDS:

Anti-inflammatory activity; Plantago major L.; hepatoprotective activity; rat

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