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Nat Rev Genet. 2010 Jun;11(6):439-46. doi: 10.1038/nrg2765. Epub 2010 May 5.

Insulators and promoters: closer than we think.

Author information

1
Department of Molecular Cell and Developmental Biology, Sinsheimer Labs, University of California, Santa Cruz, California 95064, USA.

Abstract

Insulators prevent promiscuous gene regulation by restricting the action of enhancers and silencers. Recent studies have revealed a number of similarities between insulators and promoters, including binding of specific transcription factors, chromatin-modification signatures and localization to specific subnuclear positions. We propose that enhancer-blockers and silencing barrier-insulators might have evolved as specialized derivatives of promoters and that the two types of element use related mechanisms to mediate their distinct functions. These insights can help to reconcile different models of insulator action.

PMID:
20442713
PMCID:
PMC3477808
DOI:
10.1038/nrg2765
[Indexed for MEDLINE]
Free PMC Article

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