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J Am Chem Soc. 2010 May 26;132(20):6910-1. doi: 10.1021/ja103080d.

Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes.

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1
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. dschi064@uottawa.ca

Abstract

The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.

PMID:
20441195
DOI:
10.1021/ja103080d
[Indexed for MEDLINE]
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