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Oncogene. 2010 Jul 8;29(27):3873-80. doi: 10.1038/onc.2010.141. Epub 2010 May 3.

Cancer-selective apoptotic effects of extracellular and intracellular Par-4.

Author information

1
Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA.

Abstract

Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

PMID:
20440265
PMCID:
PMC2900490
DOI:
10.1038/onc.2010.141
[Indexed for MEDLINE]
Free PMC Article

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