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J Clin Invest. 2010 May;120(5):1368-79. doi: 10.1172/JCI41911. Epub 2010 May 3.

Trafficking of immune cells in the central nervous system.

Author information

1
Division of Biomedical Sciences, University of California, Riverside, California 92521, USA. emmaw@ucr.edu

Abstract

The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with the CNS can also be deleterious. Therefore, control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.

PMID:
20440079
PMCID:
PMC2860945
DOI:
10.1172/JCI41911
[Indexed for MEDLINE]
Free PMC Article

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