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Proc Natl Acad Sci U S A. 2010 May 18;107(20):9305-10. doi: 10.1073/pnas.1004492107. Epub 2010 May 3.

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice.

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1
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA.

Abstract

The nonobese diabetic (NOD) mouse strain has a genetic deficiency in natural killer (NK) cells. This defect underlies this strain's utility in several experimental settings; in particular, it promotes engraftment of human tissue in NOD hosts during the generation of "humanized" mouse models. We have mapped the major NK-cell defect in the NOD vs. C57BL/6 (B6) strain to an inadequately expressed Il15 allele. Treatment of NOD mice with a reagent that specifically enhances interleukin (IL)-15 bioavailability normalized NK-cell numbers and activity in the absence of nonspecific stimulation. These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds.

PMID:
20439722
PMCID:
PMC2889097
DOI:
10.1073/pnas.1004492107
[Indexed for MEDLINE]
Free PMC Article
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