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Vaccine. 2010 Jun 11;28(26):4235-48. doi: 10.1016/j.vaccine.2010.04.052. Epub 2010 May 14.

Factors underlying parental decisions about combination childhood vaccinations including MMR: a systematic review.

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Centre for Patient Safety and Service Quality, Imperial College London, St. Mary's Hospital Campus, London W2 1NY, United Kingdom.


Suboptimal childhood vaccination uptake results in disease outbreaks, and in developed countries is largely attributable to parental choice. To inform evidence-based interventions, we conducted a systematic review of factors underlying parental vaccination decisions. Thirty-one studies were reviewed. Outcomes and methods are disparate, which limits synthesis; however parents are consistently shown to act in line with their attitudes to combination childhood vaccinations. Vaccine-declining parents believe that vaccines are unsafe and ineffective and that the diseases they are given to prevent are mild and uncommon; they mistrust their health professionals, Government and officially-endorsed vaccine research but trust media and non-official information sources and resent perceived pressure to risk their own child's safety for public health benefit. Interventions should focus on detailed decision mechanisms including disease-related anticipated regret and perception of anecdotal information as statistically representative. Self-reported vaccine uptake, retrospective attitude assessment and unrepresentative samples limit the reliability of reviewed data - methodological improvements are required in this area.

[Indexed for MEDLINE]

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