Format

Send to

Choose Destination
Microb Drug Resist. 2010 Jun;16(2):87-9. doi: 10.1089/mdr.2009.0131.

RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex.

Author information

1
Department of Infectious Disease, Wyeth Research, Pearl River, New York, USA. alexey.ruzin@novartis.com

Abstract

The relationship between expression of adeABC and minimal inhibitory concentration (MIC) of tigecycline was investigated by RT-PCR and statistical analyses in a population of 106 clinical isolates (MIC range, 0.0313-16 microg/ml) of Acinetobacter calcoaceticus-Acinetobacter baumannii complex. There was a statistically significant linear relationship (p < 0.0001) between log-transformed expression values and log-transformed MIC values, indicating that overexpression of AdeABC efflux pump is a prevalent mechanism for decreased susceptibility to tigecycline in A. calcoaceticus-A. baumannii complex.

PMID:
20438348
DOI:
10.1089/mdr.2009.0131
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center