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Ann Neurol. 2010 May;67(5):689-93. doi: 10.1002/ana.21989.

Endogenous neurosteroid synthesis modulates seizure frequency.

Author information

1
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.

Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

PMID:
20437568
PMCID:
PMC2918659
DOI:
10.1002/ana.21989
[Indexed for MEDLINE]
Free PMC Article

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