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Proc IEEE Swarm Intell Symp. 2005 Jun 8;2005:181-184.

DNA Motif Detection Using Particle Swarm Optimization and Expectation-Maximization.

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1
Department of Computer Science and Computer Engineering, University of Louisville, Louisville, KY 40292, cthard01@louisville.edu.

Abstract

Motif discovery, the process of discovering a meaningful pattern of nucleotides or amino acids that is shared by two or more molecules, is an important part of the study of gene function. In this paper, we propose a hybrid motif discovery approach based upon a combination of Particle Swarm Optimization (PSO) and the Expectation-Maximization (EM) algorithm. In the proposed algorithm, we use PSO to generate a seed for the EM algorithm.

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