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RNA Biol. 2010 May-Jun;7(3):300-4. Epub 2010 May 21.

The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.

Author information

1
Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.

Abstract

Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.

PMID:
20436283
PMCID:
PMC3008649
DOI:
10.4161/rna.7.3.11837
[Indexed for MEDLINE]
Free PMC Article

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