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Am J Obstet Gynecol. 2010 Aug;203(2):153.e1-9. doi: 10.1016/j.ajog.2010.02.058. Epub 2010 May 1.

Metabolic effects of soy supplementation in postmenopausal Caucasian and African American women: a randomized, placebo-controlled trial.

Author information

1
Department of Obstetrics and Gynecology, the University of Alabama School of Medicine at Birmingham, AL, USA.

Abstract

OBJECTIVE:

We sought to determine the effect of daily soy supplementation on abdominal fat, glucose metabolism, and circulating inflammatory markers and adipokines in obese, postmenopausal Caucasian and African American women.

STUDY DESIGN:

In a double-blinded controlled trial, 39 postmenopausal women were randomized to soy supplementation or to a casein placebo without isoflavones. In all, 33 completed the study and were analyzed. At baseline and at 3 months, glucose disposal and insulin secretion were measured using hyperglycemic clamps, body composition and body fat distribution were measured by computed tomographic scan and dual energy x-ray absorptiometry, and serum levels of C-reactive protein, interleukin-6, tumor necrosis factor-alpha, leptin, and adiponectin were measured by immunoassay.

RESULTS:

Soy supplementation reduced total and subcutaneous abdominal fat and interleukin-6. No difference between groups was noted for glucose metabolism, C-reactive protein, tumor necrosis factor-alpha, leptin, or adiponectin.

CONCLUSION:

Soy supplementation reduced abdominal fat in obese postmenopausal women. Caucasians primarily lost subcutaneous and total abdominal fat, and African Americans primarily lost total body fat.

PMID:
20435291
PMCID:
PMC3206645
DOI:
10.1016/j.ajog.2010.02.058
[Indexed for MEDLINE]
Free PMC Article
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