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Cell. 2010 Apr 30;141(3):404-6. doi: 10.1016/j.cell.2010.04.013.

Guiding endosomal maturation.

Author information

1
Department of Biology/Chemistry, University of Osnabrück, Barbarastrasse 13, Osnabrück 49076, Germany.

Abstract

In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).

PMID:
20434982
DOI:
10.1016/j.cell.2010.04.013
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