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Cell. 2010 Apr 30;141(3):392-8. doi: 10.1016/j.cell.2010.04.022.

Tetherin: holding on and letting go.

Author information

1
Institute of Molecular Virology, University Clinic Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany.

Abstract

Mammalian cells are equipped with so-called "restriction factors" that suppress virus replication and help to prevent virus transmission from one species to another. This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action.

PMID:
20434978
DOI:
10.1016/j.cell.2010.04.022
[Indexed for MEDLINE]
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