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Vaccine. 2010 Jul 5;28(30):4842-6. doi: 10.1016/j.vaccine.2010.04.042. Epub 2010 Apr 29.

Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA.

Author information

1
Division of Infectious Diseases, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA. gregev@hsph.harvard.edu

Abstract

Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the pneumococcal type 1 pilus declined dramatically, a decline associated with the elimination of vaccine-type (VT) strains. Here we show that between 2004 and 2007, there has been a significant increase in pilus prevalence, now exceeding rates from the pre-conjugate vaccine era. This increase is primarily due to non-VT strains. These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage.

PMID:
20434550
PMCID:
PMC2897942
DOI:
10.1016/j.vaccine.2010.04.042
[Indexed for MEDLINE]
Free PMC Article

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