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FEBS Lett. 2010 Jun 3;584(11):2485-90. doi: 10.1016/j.febslet.2010.04.067. Epub 2010 Apr 29.

Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha.

Author information

1
The Institute of Gastroenterology and Liver Disease, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Erratum in

  • FEBS Lett. 2010 Jul 16;584(14):3239. Har-Noy, Ofir [added].

Abstract

Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1alpha, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.

PMID:
20434445
DOI:
10.1016/j.febslet.2010.04.067
[Indexed for MEDLINE]
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