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Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. doi: 10.1016/j.bmcl.2010.04.009. Epub 2010 Apr 9.

A vHTS approach for the identification of beta-adrenoceptor ligands.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany. stefan.tasler@4sc.com

Abstract

Using a vHTS based on a pharmacophore alignment on known beta3-adrenoceptor ligands, a set of intriguing beta-adrenoceptor ligands was identified, optimization of which resulted in a selective and potent human beta2-AR antagonist.

PMID:
20434333
DOI:
10.1016/j.bmcl.2010.04.009
[Indexed for MEDLINE]

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