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Autoimmun Rev. 2010 Jun;9(8):583-7. doi: 10.1016/j.autrev.2010.04.003. Epub 2010 Apr 28.

PD-1, gender, and autoimmunity.

Author information

1
Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA.

Abstract

Programmed death 1 (PD-1) and its ligands (PD-L1 and PD-L2) are responsible for inhibitory T cell signaling that helps mediate the mechanisms of tolerance and immune homeostasis. The PD-1:PD-L signaling pathway has been shown to play an important role in a variety of diseases, including autoimmune conditions, chronic infection, and cancer. Recently, investigators have explored the role of sex hormones in modulating the pathway in autoimmune conditions. Exploring the effects of sex hormones on the PD-1:PD-L pathway could shed light on the gender biased nature of many autoimmune conditions as well as aide in the development of therapeutics targeting the immune system.

PMID:
20433954
PMCID:
PMC2884990
DOI:
10.1016/j.autrev.2010.04.003
[Indexed for MEDLINE]
Free PMC Article

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