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Vaccine. 2010 Jun 17;28(28):4440-4. doi: 10.1016/j.vaccine.2010.04.027. Epub 2010 Apr 28.

Low serum serotype-specific pneumococcal antibody concentrations in young children with Haemophilus influenzae serotype b (Hib) vaccine failure.

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Academic Unit of Paediatrics, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry, The Blizzard Building, 4 Newark Street, London E12AT, United Kingdom.


Serotype-specific pneumococcal antibody concentrations were measured in 164 children with Hib vaccine failure prior to routine pneumococcal immunisation. Compared with age-matched controls, a higher proportion of cases had non-protective antibody concentrations (< 0.35 microg/ml) for 7/9 (78%) serotypes tested among 2-4 year-olds, 4/9 (44%) among 5-7 year-olds, 1/9 (11%) among 8-11 year-olds and 0/9 (0%) among 12-15 year-olds (chi(2) for trend=14.0, p=0.0002). Cases aged 2-4 years were also more likely to have non-protective antibody concentrations against more serotypes than controls, suggesting that children with Hib vaccine failure may have an intact but physiologically delayed ability to develop protective antibody concentrations against encapsulated organisms.

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