Send to

Choose Destination
See comment in PubMed Commons below
Arzneimittelforschung. 1991 Feb;41(2):128-31.

Vaccinium myrtillus anthocyanosides pharmacokinetics in rats.

Author information

Research Laboratory, Inverni della Beffa S.p.A., Milan, Italy.


The pharmacokinetics of Vaccinium myrtillus anthocyanosides (VMA) have been investigated in male rats. After intravenous administration anthocyanosides undergo a rapid body distribution and their disappearance from the blood is suitably fitted by a three-compartment pharmacokinetic model. The elimination occurs mostly through urine and bile. After a single oral administration the plasma concentrations of anthocyanosides reach peak level after 15 min and then rapidly decline within 2 h. The extent of cumulative urinary and biliary elimination together with the gastrointestinal recovery demonstrates an absorption of about 5%. No hepatic first-pass effect has been observed. Despite of the modest gastrointestinal absorption and the low absolute bioavailability (1.2% of the administered dose), the plasmatic peak levels (2-3 micrograms/ml) measured after the oral treatment are in the range of biological activity reported for these substances.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center