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J Biol Chem. 2010 Jul 2;285(27):20423-7. doi: 10.1074/jbc.R110.134452. Epub 2010 Apr 29.

Common and uncommon pathogenic cascades in lysosomal storage diseases.

Author information

1
From the Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Lysosomal storage diseases (LSDs), of which about 50 are known, are caused by the defective activity of lysosomal proteins, resulting in accumulation of unmetabolized substrates. As a result, a variety of pathogenic cascades are activated such as altered calcium homeostasis, oxidative stress, inflammation, altered lipid trafficking, autophagy, endoplasmic reticulum stress, and autoimmune responses. Some of these pathways are common to many LSDs, whereas others are only altered in a subset of LSDs. We now review how these cascades impact upon LSD pathology and suggest how intervention in the pathways may lead to novel therapeutic approaches.

PMID:
20430897
PMCID:
PMC2898325
DOI:
10.1074/jbc.R110.134452
[Indexed for MEDLINE]
Free PMC Article
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