Format

Send to

Choose Destination
Ophthalmology. 2010 Jun;117(6):1113-1123.e15. doi: 10.1016/j.ophtha.2010.01.060.

Natural history of central retinal vein occlusion: an evidence-based systematic review.

Author information

1
Centre for Eye Research Australia, University of Melbourne, VIC, Australia.

Abstract

OBJECTIVE:

To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature.

CLINICAL RELEVANCE:

Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear.

METHODS:

Systemic review of all English language articles retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008. This was supplemented by hand-searching references of review articles published within the last 5 years. Two investigators independently identified all relevant observational studies evaluating the natural history of RVO and all clinical trials evaluating interventions for CRVO; an untreated control arm was included.

RESULTS:

Of 5966 citations retrieved, 53 studies were reviewed, providing 3271 eyes with CRVO for analysis of its natural history. Visual acuity (VA) was generally poor at baseline (<20/40) and decreased further over time. Although 6 studies reported an improvement in VA, none of these improvements resulted in VA better than 20/40. Up to 34% of eyes with nonischemic CRVO converted to ischemic CRVO over a 3-year period. In ischemic CRVO cases, neovascular glaucoma developed in at least 23% of eyes within 15 months. In nonischemic CRVO cases, macular edema resolved in approximately 30% of eyes over time, and subsequent neovascular glaucoma was rare.

CONCLUSIONS:

Untreated eyes with CRVO generally had poor VA, which declined further over time. One quarter of eyes with nonischemic CRVO converted to ischemic CRVO.

PMID:
20430446
DOI:
10.1016/j.ophtha.2010.01.060
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center