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J Cogn Neurosci. 2011 May;23(5):1218-29. doi: 10.1162/jocn.2010.21514. Epub 2010 Apr 30.

Habitual versus goal-directed action control in Parkinson disease.

Author information

1
Department of Psychology, Amsterdam Center for Study of Adaptive Control in Brain and Behavior (Acacia), University of Amsterdam, Roeterstraat 15, 1018 WB, The Netherlands. s.dewit@uva.nl

Abstract

This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus-response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus-response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.

PMID:
20429859
DOI:
10.1162/jocn.2010.21514
[Indexed for MEDLINE]

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