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Synlett. 2008 Jun 1;2008(10):1510-1514.

Synthesis of 8-Heteroaryl-2'-deoxyguanosine Derivatives.

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1
Department of Chemistry, College of Natural Sciences, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico, PR-00931.

Abstract

We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.

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