Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2010 May 15;20(10):3017-20. doi: 10.1016/j.bmcl.2010.04.012. Epub 2010 Apr 11.

5-Functionalized indazoles as glucocorticoid receptor agonists.

Author information

1
AMRI, Albany, NY 12212-5098, USA.

Abstract

An indazole based series of glucocorticoid receptor agonists is reported. The SAR exploration of this scaffold yielded compounds with nanomolar affinity for the glucocorticoid receptor with indications of selectivity for the preferred transrepression mechanism; in vivo efficacy was observed in the mouse LPS induced TNFalpha model for compound 28.

PMID:
20427184
DOI:
10.1016/j.bmcl.2010.04.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center