Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Biotechnol. 2010 Jul;28(7):363-70. doi: 10.1016/j.tibtech.2010.04.002. Epub 2010 Apr 26.

(19)F MRI for quantitative in vivo cell tracking.

Author information

1
Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

Abstract

Cellular therapy, including stem cell transplants and dendritic cell vaccines, is typically monitored for dosage optimization, accurate delivery, and localization using noninvasive imaging, of which magnetic resonance imaging (MRI) is a key modality. (19)F MRI retains the advantages of MRI as an imaging modality, and also allows direct detection of labeled cells for unambiguous identification and quantification, unlike typical metal-based contrast agents. Recent developments in (19)F MRI-based in vivo cell quantification, the existing clinical use of (19)F compounds and current explosive interest in cellular therapeutics have brought (19)F imaging technology closer to clinical application. We review the application of (19)F MRI to cell tracking, discussing intracellular (19)F labels, cell labeling and in vivo quantification, as well as the potential clinical uses of (19)F MRI.

PMID:
20427096
PMCID:
PMC2902646
DOI:
10.1016/j.tibtech.2010.04.002
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center