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Am J Med. 1991 Jun;90(6):701-6.

Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury.

Author information

1
Gastrointestinal Section, Veterans Affairs Medical Center, Bronx, New York 10468.

Abstract

OBJECTIVE:

To assess the effects of chronic xerostomia on parameters of gastroesophageal reflux and esophagitis.

DESIGN:

Observational study of a cohort of male patients with xerostomia and age-matched control subjects.

SETTING:

Tertiary-care Veterans Affairs Medical Center.

SUBJECTS:

Sixteen male patients with chronic xerostomia secondary to radiation for head and neck cancers or medications. Nineteen age-matched male control subjects with comparable alcohol and smoking histories.

MEASUREMENTS AND MAIN RESULTS:

Esophageal motility was similar in patients with xerostomia and controls. Clearance of acid from the esophagus and 24-hour intraesophageal pH were markedly abnormal in patients with xerostomia. Symptoms and signs of esophagitis were significantly more frequent in subjects with xerostomia.

CONCLUSIONS:

Chronic xerostomia may predispose to esophageal injury, at least in part, by decreasing the clearance of acid from the esophagus and altering 24-hour intraesophageal pH. Esophageal injury is a previously unreported complication of long-term salivary deficiency.

PMID:
2042685
[Indexed for MEDLINE]

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