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J Nat Prod. 2010 May 28;73(5):988-91. doi: 10.1021/np100009j.

Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica.

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Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.


Two new (1 and 2) and six known hasubanan alkaloids (3-8) and one morphinane alkaloid (9) were isolated from the leaves of the North Queensland rainforest vine Stephania japonica. The structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR spectra. The hasubanan alkaloids showed affinity for the human delta-opioid receptor with IC(50) values ranging from 0.7 to 46 microM. The compounds were also tested for their affinity to micro- and kappa-opioid receptors and shown to be inactive against kappa-opioid receptors, but were of similar potency against the micro-opioid receptor.

[Indexed for MEDLINE]

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