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J Med Chem. 2010 May 27;53(10):3927-36. doi: 10.1021/jm9016366.

Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.

Author information

1
Biota Europe Ltd., Begbroke Science Park, Yarnton, Oxfordshire, UK. d.haydon@biota.com.au

Abstract

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.

PMID:
20426423
PMCID:
PMC2874265
DOI:
10.1021/jm9016366
[Indexed for MEDLINE]
Free PMC Article

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