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Curr Rheumatol Rep. 2010 Jun;12(3):221-8. doi: 10.1007/s11926-010-0102-5.

Theories of the pathogenesis of inclusion body myositis.

Author information

1
Department of Neurology, Division of Neuromuscular Disease, Brigham and Women's Hospital, and Children's Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. sagreenberg@partners.org

Abstract

Inclusion body myositis is a progressive disease of the skeletal muscle. Here, specific theories of its pathogenesis are reviewed and general considerations pertaining to modeling of this disease discussed. Understanding of inclusion body myositis disease mechanism remains extremely poor. Current published animal models do not represent the disease. Future studies need to consider the critical role of biomarkers and methodologic issues in their discovery.

PMID:
20425523
PMCID:
PMC2929917
DOI:
10.1007/s11926-010-0102-5
[Indexed for MEDLINE]
Free PMC Article

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