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Curr Diab Rep. 2010 Feb;10(1):55-60. doi: 10.1007/s11892-009-0090-x.

Cholesterol in beta-cell dysfunction: the emerging connection between HDL cholesterol and type 2 diabetes.

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Child and Family Research Institute, 980 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.


Beta-cell dysfunction is a critical step in the pathogenesis of type 2 diabetes. The mechanisms responsible for beta-cell death and dysfunction remain incompletely understood, but include glucolipotoxicity, the deleterious metabolic milieu created by high plasma concentrations of glucose and lipid species. Recently, an important role has emerged for cholesterol in this process. In this article, we review recent advances in our understanding of the role of ABCA1 and cholesterol metabolism in beta-cell function, with particular attention to insights gained from human studies.

[Indexed for MEDLINE]

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