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Nat Rev Neurosci. 2010 Jun;11(6):436-49. doi: 10.1038/nrn2809. Epub 2010 Apr 28.

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

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1
Department of Neurology, Brigham and Women's and Massachusetts General Hospitals, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale.

PMID:
20424620
DOI:
10.1038/nrn2809
[Indexed for MEDLINE]
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