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Intern Med. 2010;49(8):791-4. Epub 2010 Apr 15.

Synchronized changes in serum vascular endothelial growth factor during the clinical course of chronic systemic capillary leak syndrome.

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Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube.


Systemic capillary leak syndrome (SCLS) is a rare disease characterized by leakage of plasma from blood vessels into the interstitial space due to increased capillary permeability. We describe a 24-year-old man who was hospitalized with systemic edema, hypoalbuminemia, and disseminated intravascular coagulation. After extensive investigative procedures, he was diagnosed with chronic SCLS and made a gradual recovery after starting on prednisolone, terbutaline, and theophylline. We measured the patient's serum vascular endothelial growth factor (VEGF) over time and found a relationship between serum VEGF and the clinical course.

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