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Blood. 2010 Jul 29;116(4):631-9. doi: 10.1182/blood-2010-01-264051. Epub 2010 Apr 27.

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis.

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1
First Department of Internal Medicine Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Abstract

Thrombosis is a common complication of end-stage renal disease, particularly in patients on hemodialysis. Although substantial progress has been made in preventing thrombotic complications in various other groups of patients, the mechanisms of thrombosis during hemodialysis require clarification. In this report, we demonstrate that complement activation triggered by hemodialysis biomaterials, and the subsequent generation of the complement anaphylatoxin C5a, results in the expression of functionally active tissue factor (TF) in peripheral blood neutrophils. Because TF is a key initiator of coagulation in vivo, we postulate that the recurring complement activation that occurs during long-term hemodialysis contributes to thrombosis in dialyzed end-stage renal disease patients. Furthermore, we found that complement contributed to the induction of granulocyte colony-stimulating factor, which has been implicated in the pathogenesis of thrombosis in patients treated with the recombinant form of this molecule. Importantly, the inhibition of complement activation attenuated the TF expression and granulocyte colony-stimulating factor induction in blood passing through a hemodialysis circuit, suggesting that the complement system could become a new therapeutic target for preventing thrombosis in patients with chronic renal failure who are maintained on hemodialysis.

PMID:
20424189
PMCID:
PMC3086498
DOI:
10.1182/blood-2010-01-264051
[Indexed for MEDLINE]
Free PMC Article
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