Format

Send to

Choose Destination
See comment in PubMed Commons below
Org Lett. 2010 May 21;12(10):2398-401. doi: 10.1021/ol100774p.

Synthesis of a DOTA--biotin conjugate for radionuclide chelation via Cu-free click chemistry.

Author information

  • 1Department of Radiology and Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. michael-schultz@uiowa.edu

Abstract

A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially general and convenient means of preparing targeted radiolabeling and radiotherapeutic agents.

PMID:
20423109
DOI:
10.1021/ol100774p
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center