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Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(3):397-400.

[Important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of active ingredients of Chinese materia medica].

[Article in Chinese]

Author information

1
Nanjing University of Chinese Medicine, Nanjing 210029, China. bxl77@126.com

Abstract

Oral drug bioavailability depends on gastrointestinal absorption, intestinal transporters and metabolism enzymes are the important factors in drug gastrointestinal absorption and they can also be induced or inhibited by the active ingredients of Chinese materia medica. This article presents important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of the active ingredients of Chinese materia medica, and points out the importance of research on transport and metabolism of the active ingredients of Chinese materia medica in Chinese extract and Chinese medicinal formulae.

PMID:
20423015
[Indexed for MEDLINE]

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