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Gac Med Mex. 2010 Jan-Feb;146(1):31-5.

[Serum levels of beta2 microglobulin and ultrasensitive c-reactive protein as markers of histological activity in ulcerative colitis].

[Article in Spanish]

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Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", SSA, México D.F., México.



There is currently increasing interest in research focused on new, non-invasive biochemical markers with better efficacy for evaluating endoscopic activity in patients with inflammatory bowel disease (IBD). In the present study, we determined the diagnostic utility of high sensitive C-reactive protein (hs CRP) and beta2 microglobulin (beta2M) levels and analyzed their correlation with the histological activity of ulcerative colitis (UC).


A total of 60 consecutive patients with UC were studied. Truelove-Witts index, histological activity, and beta2M and CRP levels were determined. Patients were grouped as non-active, mild, moderate, or severe following Riley's classification. Statistical analysis was performed using descriptive statistics.


The mean age of the patients was 41.3 +/- 14.5 years. Thirty patients were women (50%). Twenty-one patients had distal UC (35%). The correlations between serum hsCRP and beta2M with histological activity showed coefficients of 0.39 (p = 0.01) and 0.33 (p = 0.02), respectively. The diagnostic utility was determined by ROC curves, which showed that the cutoff with the greatest area under the curve (AUC) for hsCRP and beta2M were > or = 0.36 (AUC = 0.73) and > or = 1.3 (AUC = 0.69), respectively.


In patients with UC, hsCRP and beta2M levels are positively correlated with histological activity.

[Indexed for MEDLINE]

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