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PLoS One. 2010 Apr 21;5(4):e10249. doi: 10.1371/journal.pone.0010249.

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.

Author information

1
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

Abstract

BACKGROUND:

The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele.

METHODOLOGY/PRINCIPAL FINDINGS:

Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA-B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the viral population revealed no evidence of variant virus in any of the individuals.

CONCLUSIONS/SIGNIFICANCE:

This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapid progressing allele and those with the HLA-B*35-Py slower progressing allele.

PMID:
20422053
PMCID:
PMC2858076
DOI:
10.1371/journal.pone.0010249
[Indexed for MEDLINE]
Free PMC Article

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