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J Clin Microbiol. 2010 Jul;48(7):2595-8. doi: 10.1128/JCM.00473-10. Epub 2010 Apr 26.

Probiotics and intestinal colonization by vancomycin-resistant enterococci in mice and humans.

Author information

1
Service des maladies infectieuses et tropicales, CHU Clermont-Ferrand, Clermont-Ferrand, France.

Abstract

We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00437580.

PMID:
20421444
PMCID:
PMC2897524
DOI:
10.1128/JCM.00473-10
[Indexed for MEDLINE]
Free PMC Article
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