Helicobacter pylori virulence factor genotypes in children in the United States: clues about genotype and outcome relationships

J Clin Microbiol. 2010 Jul;48(7):2550-1. doi: 10.1128/JCM.00114-10. Epub 2010 Apr 26.

Abstract

The most common Helicobacter pylori genotype among 37 U.S. children was cagA positive, vacA s1m1, and oipA "on" (n = 17, 45.9%), followed by cagA negative, vacA s2m2, and oipA "off" (n = 8, 21.6%), similar to the pattern in adults. cagA positivity was more common in blacks than in whites (i.e., 100% versus 56.5%, P = 0.032).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Antigens, Bacterial / genetics
  • Bacterial Proteins / genetics
  • Child
  • Child, Preschool
  • Disease Susceptibility
  • Genotype
  • Helicobacter Infections* / ethnology
  • Helicobacter Infections* / microbiology
  • Helicobacter pylori* / genetics
  • Helicobacter pylori* / pathogenicity
  • Humans
  • Racial Groups / ethnology*
  • United States
  • Virulence Factors / genetics*

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • Virulence Factors
  • cagA protein, Helicobacter pylori