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Eur Neuropsychopharmacol. 2010 Jul;20(7):459-66. doi: 10.1016/j.euroneuro.2010.03.007. Epub 2010 Apr 24.

The change of prefrontal QEEG theta cordance as a predictor of response to bupropion treatment in patients who had failed to respond to previous antidepressant treatments.

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1
Prague Psychiatric Center, Ustavni 91, Prague 8-Bohnice, 181 03, Czech Republic. bares@pcp.lf3.cuni.cz

Abstract

The aim of the study was to examine whether the reduction of theta prefrontal quantitative EEG (QEEG) cordance after one week of bupropion administration is a predictor of response to a 4-week treatment in patients that had failed to respond to previous antidepressant treatments.

METHOD:

EEG data of 18 inpatients were monitored at baseline and after one week. QEEG cordance was computed at 3 frontal electrodes (Fp1, Fp2, Fz). Response to treatment was defined as a >/=50% reduction of MADRS score.

RESULTS:

Nine of the eleven responders and one of the seven non-responders showed decreased prefrontal cordance value after the first week of treatment (p=0.01). Positive and negative predictive values of cordance reduction for the prediction of response to the treatment were 0.9 and 0.75, respectively.

CONCLUSION:

Similar to other antidepressants, the reduction of prefrontal QEEG cordance might be helpful in the prediction of the acute outcome of bupropion treatment.

PMID:
20421161
DOI:
10.1016/j.euroneuro.2010.03.007
[Indexed for MEDLINE]
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