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J Trauma Stress. 2010 Apr;23(2):282-7. doi: 10.1002/jts.20517.

The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: a pilot study.

Author information

1
Alpert Brown Medical School and Bradley/Hasbro Children's Research Center, One Hoppin Street, Suite 204, Providence, Rhode Island 02903, USA.

Abstract

Initial research supports the use of propranolol to prevent posttraumatic stress disorder (PTSD); research has not examined pharmacological prevention for children. Twenty-nine injury patients (ages 10-18 years old) at risk for PTSD were randomized to a double-blind 10-day trial of propranolol or placebo initiated within 12 hours postadmission. Six-week PTSD symptoms and heart rate were assessed. Although intent-to-treat analyses revealed no group differences, findings supported a significant interaction between gender and treatment in medication-adherent participants, Delta R(2) = .21. Whereas girls receiving propranolol reported more PTSD symptoms relative to girls receiving placebo, Delta R(2) = .44, boys receiving propranolol showed a nonsignificant trend toward fewer PTSD symptoms than boys receiving placebo, Delta R(2) = .32. Findings inform gender differences regarding pharmacological PTSD prevention in youth.

PMID:
20419738
PMCID:
PMC3050589
DOI:
10.1002/jts.20517
[Indexed for MEDLINE]
Free PMC Article

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