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J Struct Funct Genomics. 2010 Jun;11(2):167-80. doi: 10.1007/s10969-010-9090-y. Epub 2010 Apr 24.

The Scottish Structural Proteomics Facility: targets, methods and outputs.

Author information

1
Biomedical Sciences Research Complex, University of St Andrews, St Andrews, KY16 9ST, UK.

Abstract

The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.

PMID:
20419351
PMCID:
PMC2883930
DOI:
10.1007/s10969-010-9090-y
[Indexed for MEDLINE]
Free PMC Article

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