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Trends Immunol. 2010 Jun;31(6):205-11. doi: 10.1016/j.it.2010.03.002. Epub 2010 Apr 24.

Activation of B cells by antigens on follicular dendritic cells.

Author information

1
Department of Microbiology and Immunology, Virginia Commonwealth University, PO Box 980678, Richmond, VA 23298-0678, USA.

Abstract

A need for antigen-processing and presentation to B cells is not widely appreciated. However, cross-linking of multiple B cell receptors (BCRs) by T-independent antigens delivers a potent signal that induces antibody responses. Such BCR cross-linking also occurs in germinal centers where follicular dendritic cells (FDCs) present multimerized antigens as periodically arranged antigen-antibody complexes (ICs). Unlike T cells that recognize antigens as peptide-MHC complexes, optimal B cell-responses are induced by multimerized FDC-ICs that simultaneously engage multiple BCRs. FDC-FcgammaRIIB mediates IC-periodicity and FDC-BAFF, FDC-IL-6 and FDC-C4bBP are co-stimulators. Remarkably, specific antibody responses can be induced by FDC-ICs in the absence of T cells, opening up the exciting possibility that people with T cell insufficiencies may be immunized with T-dependent vaccines via FDC-ICs.

PMID:
20418164
PMCID:
PMC2886728
DOI:
10.1016/j.it.2010.03.002
[Indexed for MEDLINE]
Free PMC Article

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