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Vaccine. 2010 Jun 7;28(25):4162-8. doi: 10.1016/j.vaccine.2010.04.015. Epub 2010 Apr 23.

Rotavirus vaccination in northeast Brazil: a laudable intervention, but can it lead to cost-savings?

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  • 1Paediatric Department, University of Pisa, Via Di Pratale 18/A, 56127 Pisa, Italy.


This study assessed the family and heath system's costs due to diarrhoea in children <2 years old, before/after the introduction of a rotavirus vaccine in Brazil in 2006. Information on diarrhoea health care costs and morbidity were obtained from the primary health care system, the National Public Health database (2004-2008) and care-givers. Diarrhoea ambulatory consultations and hospitalizations had a declining trend during the entire period, with additional steeper reductions after vaccine introduction. The vaccine thus is associated with reduced diarrhoea consultations and hospitalization costs and families' out-of-pocket expenses. Despite these gains, the overall health system's costs have increased.

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