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Psychiatry Res. 2010 May 30;182(2):187-90. doi: 10.1016/j.pscychresns.2010.01.006. Epub 2010 Apr 22.

Insular cortex volume in established bipolar affective disorder: a preliminary MRI study.

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Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia.


This structural magnetic resonance imaging study investigated insular cortex volume in 26 patients with bipolar I disorder and 24 matched controls. While insular volume did not differ between these groups, exploratory analyses demonstrated that the number of depressive episodes correlated negatively with the anterior insular volume in the patients, suggesting it may have a role in the pathophysiology of bipolar disorder.

[Indexed for MEDLINE]

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