Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Exp Immunol. 2010 Apr;160(1):22-6. doi: 10.1111/j.1365-2249.2010.04129.x.

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the role of infections in allergy: atopic asthma as a paradigm.

Author information

1
Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Australia. patrick@ichr.uwa.edu.au

Abstract

Earlier iterations of the 'hygiene hypothesis', in which infections during childhood protect against allergic disease by stimulation of the T helper type 2 (Th2)-antagonistic Th1 immunity, have been supplanted progressively by a broader understanding of the complexities of the underlying cellular and molecular interactions. Most notably, it is now clear that whole certain types of microbial exposure, in particular from normal gastrointestinal flora, may provide key signals driving postnatal development of immune competence, including mechanisms responsible for natural resistance to allergic sensitization. Other types of infections can exert converse effects and promote allergic disease. We review below recent findings relating to both sides of this complex picture.

PMID:
20415847
PMCID:
PMC2841831
DOI:
10.1111/j.1365-2249.2010.04129.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center