Format

Send to

Choose Destination
Nat Rev Immunol. 2010 May;10(5):301-16. doi: 10.1038/nri2761.

Therapeutic antibodies for autoimmunity and inflammation.

Author information

1
Department of Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. acc@gene.com

Abstract

The development of therapeutic antibodies has evolved over the past decade into a mainstay of therapeutic options for patients with autoimmune and inflammatory diseases. Substantial advances in understanding the biology of human diseases have been made and tremendous benefit to patients has been gained with the first generation of therapeutic antibodies. The lessons learnt from these antibodies have provided the foundation for the discovery and development of future therapeutic antibodies. Here we review how key insights obtained from the development of therapeutic antibodies complemented by newer antibody engineering technologies are delivering a second generation of therapeutic antibodies with promise for greater clinical efficacy and safety.

PMID:
20414204
DOI:
10.1038/nri2761
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center